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Modulation of anterior pituitary dopamine receptors by estradiol 17-β: Dose-response relationship

✍ Scribed by S.F. Ali; Dr. E.J. Peck Jr.

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 684 KB
Volume: 13
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490130404

No coin nor oath required. For personal study only.

✦ Synopsis

Exposure of ovariectomized rats to estradiol-17-0 for 48-96 hr resulted in a dosedependent reduction in the number but not the & of D-2 dopamine receptors of the anterior pituitary. No influence of estrogen was observed on dopamine or muscarinic acetylcholine receptors of caudate or hypothalamus. The dose-response relationship observed suggested that the influence of estrogen is directly on the pituitary, not secondary to the alteration of dopaminergic systems in the hypothalamus.

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