Modulation of Adriamycin cytotoxicity and transport in drug-sensitive and multidrug-resistant Chinese hamster ovary cells by hyperthermia and cyclosporin A

The effect of hyperthermia on the uptake

The effect of hyperthermia on the uptake and cytotoxicity of melphalan in chinese hamster ovary cells

✍ Diana A. Bates; William J. Mackillop 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 564 KB

Reversal of typical multidrug resistance

Reversal of typical multidrug resistance by cyclosporin and its non-immunosuppressive analogue SDZ PSC 833 in Chinese hamster ovary cells expressing themdr1 phenotype

✍ Peter A. W. Boekhorst; Jan Kapel; Martijn Schoester; Pieter Sonneveld 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 511 KB

Effects of cyclosporin a and verapamil o

Effects of cyclosporin a and verapamil on the intracellular daunorubicin accumulation in chinese hamster ovary cells with increasing levels of drug-resistance

✍ M. H. Silbermann; A. W. M. Boersma; A. L. W. Jamssen; R. J. Scheper; H. Herweije 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 961 KB

## Multidrug -resistance (MDR) is characterized by the presence of a 170 kDa glycoprotein (P-glycoprotein) in the plasma membrane. P-glycoprotein is thought to act as an efflux pump, leading to reduced drug accumulation in MDR cells. This defect in drug accumulation can be overcome by membrane tra

Insulin receptor and altered glucose tra

Insulin receptor and altered glucose transport in a monensin-resistant mutant of Chinese hamster ovary cell

✍ Tadashi Seguchi; Akihiko Yoshimura; Mayumi Ono; Satoshi Shite; Michihiro Kasahar 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 802 KB

A monensin-resistant mutant Monr-31, derived from Chinese hamster ovary (CHO) cell line, has been shown to have a reduced number of insulin receptors and a reduction in glucose uptake in response to insulin. We have further investigated the possibility that altered glucose uptake in Monr-31 cells i

Identification of anthracyclines and rel

Identification of anthracyclines and related agents that retain preferential activity over Adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A

✍ Helen M. Coley; Peter R. Twentyman; Paul Workman 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 46 KB

Identification of anthracyclines and rel

Identification of anthracyclines and related agents that retain preferential activity over Adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A

✍ Helen M. Coley; Peter R. Twentyman; Paul Workman 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 804 KB

A range of anthracyclines and related compounds were evaluated for activity against murine and human cell lines exhibiting multidrug resistance (MDR). Cell lines used were the NCI-H69 human small-cell lung cancer line and the EMT6 murine mammary tumour line, together with their multidrug-resistant c