Since physostigmine (Phy) is presently used in the experimental treatment of Alzheimer disease (AD) patients by means of intracerebral ventricular (i.c.v.) administration, we designed a study to determine the effect of the drug administered by the same route on the cholinergic system of the rat brai
Modulation of acetylcholine receptor in rat diaphragm by anti-receptor sera
β Scribed by HEINEMANN, S.; MERLIE, J.; LINDSTROM, J.
- Book ID
- 109709996
- Publisher
- Nature Publishing Group
- Year
- 1978
- Tongue
- English
- Weight
- 480 KB
- Volume
- 274
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/274065a0
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Myasthenia gravis (MG) is a neuromuscular disorder of man caused by a humoral response to the acetylcholine receptor (AChR). Most of the antibodies in MG and in experimental autoimmune myasthenia gravis (EAMG) are directed to the extracellular portion of the AChR alpha subunit, and within it, primar
## Abstract Both acetylcholine receptor (AChR) and antibodies capable of binding to the AChR can be measured using the recently developed enzymelinked immunosorbent assay (ELISA). The assay is very sensitive and reproducible. Because of the relative simplicity of the ELISA in comparison to radioimm