Measurement of acetylcholine receptor and anti-receptor antibodies by ELISA
β Scribed by Dr. N. L. Norcross; I. J. Griffith; J. A. Lettieri
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 347 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0148-639X
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Both acetylcholine receptor (AChR) and antibodies capable of binding to the AChR can be measured using the recently developed enzymelinked immunosorbent assay (ELISA). The assay is very sensitive and reproducible. Because of the relative simplicity of the ELISA in comparison to radioimmunoassay procedures currently used to measure antiβAChR antibodies, the ELISA may prove valuable as a clinical diagnostic tool for the human disease myasthenia gravis.
π SIMILAR VOLUMES
Myasthenia gravis (MG) is a neuromuscular disorder of man caused by a humoral response to the acetylcholine receptor (AChR). Most of the antibodies in MG and in experimental autoimmune myasthenia gravis (EAMG) are directed to the extracellular portion of the AChR alpha subunit, and within it, primar