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Modulation in the expression of p70S6 kinase impairs the engraftment and self-renewal of hematopoietic stem cells

✍ Scribed by Ghosh, Joydeep; Ramdas, Baskar; Chatterjee, Anindya; Ma, Peilin; Kobayashi, Michihiro; Mali, Raghuveer; Liu, Yan; Plas, David; Kapur, Reuben

Book ID: 125816979
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 57 KB
Volume: 42
Category: Article
ISSN: 0301-472X
DOI: 10.1016/j.exphem.2014.07.125

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## Abstract Self‐renewal and differentiation of stem cells are tightly regulated processes subject to intrinsic and extrinsic signals. Molecular chaperones and co‐chaperones, especially heat shock proteins (Hsp), are ubiquitous molecules involved in the modulation of protein conformational and comp