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A critical role for Smad4 in the self-renewal of hematopoietic stem cells

✍ Scribed by Göran Karlsson; Ulrika Blank; Jennifer L Moody; Sofie Singbrant; Stefan Karlsson

Book ID
116304518
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
56 KB
Volume
40
Category
Article
ISSN
1079-9796

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Haematopoietic stem cells (HSCs) have the ability to renew themselves and to give rise to all lineages of the blood; however, the signals that regulate HSC self-renewal remain unclear. Here we show that the Wnt signalling pathway has an important role in this process. Overexpression of activated bet