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Modulation by staurosporine of phorbol-ester-induced effects on growth and protein kinase C localization in A549 human lung carcinoma cells


Book ID
122753889
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
100 KB
Volume
8
Category
Article
ISSN
0169-5002

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Modulation by staurosporine of phorbol-e
โœ Tracey D. Bradshaw; Andreas Gescher; George R. Pettit ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 711 KB

I 2-0-tetradecanoylphorbol-I 3-acetate (TPA) and bryostatin I are activators of protein kinase C (PKC). TPA is a potent inhibitor of the growth of A549 cells, while bryostatin I exerts a weak antiproliferative effect upon this cell line. We tested the hypothesis that the PKC inhibitor staurosporine