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Differential effects of protein kinase inhibitors on cytokine and phorbol ester induced IL-8 production in human endothelial cells


Book ID
123138516
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
165 KB
Volume
3
Category
Article
ISSN
1043-4666

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Modulation by staurosporine of phorbol-e
✍ Tracey D. Bradshaw; Andreas Gescher; George R. Pettit πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 French βš– 711 KB

I 2-0-tetradecanoylphorbol-I 3-acetate (TPA) and bryostatin I are activators of protein kinase C (PKC). TPA is a potent inhibitor of the growth of A549 cells, while bryostatin I exerts a weak antiproliferative effect upon this cell line. We tested the hypothesis that the PKC inhibitor staurosporine