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Modulating therapeutic effects of the c-Src inhibitor via oestrogen receptor and human epidermal growth factor receptor 2 in breast cancer cell lines

✍ Scribed by Ping Fan; Russell E. McDaniel; Helen R. Kim; Dionyssia Clagett; Bassem Haddad; V. Craig Jordan


Book ID
119233291
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
794 KB
Volume
48
Category
Article
ISSN
0959-8049

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In C3H/10T1/2 murine fibroblasts, overexpression of both c-Src and the human epidermal growth factor (EGF) receptor 1 (HER1) is required for detection of stable complexes between the two molecules and results in hyperactivation of the receptor and synergistic increases in tumor formation in nude mic