Interest in the unique biological properties 2) of 8-iso-prostaglandin (PG) El (1), which has been isolated by Daniels et al. in the biochemical transformation of 8,11,14-eicosatrienoic acid 3) , prompted us to synthesize a series of 8-iso-prostanoids. As the reported syntheses 4-6) of 1. have not
โฆ LIBER โฆ
Modular Enantioselective Synthesis of 8-Aza-prostaglandin E 1
โ Scribed by Wang, Xiao-Gang; Wang, Ai-E; Hao, Yi; Ruan, Yuan-Ping; Huang, Pei-Qiang
- Book ID
- 121221426
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 473 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0022-3263
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## Abstract Synthesis of a novel class of fused heterotetracyclic compounds, 8__H__โ1โthiaโ8โazaโdibenzo[__e__,__h__]azulenes (**VII**), is described. Starting __N__โbenzoylโprotected 5__H__โdibenzo[__b__,__f__]azepine (**XI**, PG = Bz) was oxidized to 5โbenzoylโ10,11โepoxyโ10,11โdihydroโ5__H__โdib