✦ LIBER ✦

Modifying the biological response in acute myeloid leukemia

✍ Scribed by Anabel Arends-Merino; Richardo Giscombe; Claudio Ogier; Peter Reizenstein; Anne-Marie Sjörgen; Jerzy Wasserman

Publisher: Springer-Verlag
Year: 1982
Tongue: English
Weight: 431 KB
Volume: 14
Category: Article
ISSN: 0340-7004
DOI: 10.1007/bf00199429

No coin nor oath required. For personal study only.

✦ Synopsis

Lymphocyte response to mitogens and to lymphocyte suppressor and monocyte helper activity was studied in 18 patients with acute myeloid leukemia in complete remission, and in 17 healthy controls. Ten patients were maintained with chemotherapy alone (CT), and eight received chemoimmunotherapy with BCG + leukemic cells (CIT).

In late remission the mitogen responsiveness was increased in CT patients and decreased in CIT patients.

No significant difference in lymphocyte suppressor activity could be demonstrated between patients and controls, or between CT and CIT.

When autologous CIT monocytes were added to mitogen-stimulated lymphocytes they acted as helper cells. CT monocytes, in contrast, seemed to act as suppressor cells. Control monocytes also acted as helper cells, but to a significantly lesser degree than CIT monocytes.

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