## Abstract Sixteen children (ages 2β17) with acute promyelocytic leukemia (APL) were studied retrospectively. Diagnosis was based on clinical features and morphological criteria of the FAB classification. Bleeding diathesis was the predominant presenting symptom (>85%), associated with laboratory
Annular promyelocytes in acute myeloid leukemia
β Scribed by Peichev, M.
- Publisher
- Springer-Verlag
- Year
- 1987
- Weight
- 215 KB
- Volume
- 55
- Category
- Article
- ISSN
- 1432-0584
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β¦ Synopsis
Granulocytes with ring-shaped nuclei (annular granulocytes; ring granulocytes) are normal bone marrow constituents in rodents. Studies in man have shown a small number of these cells in cases of myeloproliferative diseases. Myelocytes and metamyelocytes have also been described. Similar to rodents and some other animal species, the annular promyelocyte also exists in humans. The significance of these very rare cells in human haemopoiesis becomes an interesting question.
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