Modified technique of ureteroureterostomy in rat kidney transplantation

✍ Scribed by Alexander Pietsch; Philipp C. Nett; Hans W. Sollinger; Debra A. Hullett

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 199 KB
• Volume: 24
• Category: Article
• ISSN: 0738-1085
• DOI: 10.1002/micr.20033

✦ Synopsis

Different strain combinations of rats are available to study immunological and transplant-related problems in the models of kidney transplantation. Although numerous modifications of surgical techniques for ureteric reconstruction are evaluated in order to reduce complications and to extend long-term survival, ureteric complications still occur frequently, especially when the difference in diameter of both donor and host ureters is disproportionate. Instead of using the current nonsplinted ureteroureterostomy (method A), a versatile and rapid technical modification (method B) was developed to perform reconstruction of ureters with disproportionate diameters. The overall incidence of ureteric complications was 80% (8/10) using method A, whereas this rate was significantly reduced to 15% (3/20) using method B (P < 0.001). Our modification proves the feasibility of nonsplinted ureteroureterostomy in a technical, highly demanding rat model of kidney transplantation with an acceptable rate of ureteric complication, considering the disproportionate difference in diameter between the host and donor ureters.