Modified synthesis of deoxyadenosine-5'-(35S)-thiomonophosphate [dAMP (35S)] with high specific activity: An important starting material for the synthesis of deoxyadenosine-5'-(&;#945;-35S)-thiotriphosphate [dATP (&;#945;-35S)]

Synthesis of deoxyadenosine-5′-(35S)-thi

Synthesis of deoxyadenosine-5′-(35S)-thiomonophosphate [dAMP(35S)] of high specific activity – a key intermediate for the synthesis of Sp-deoxyadenosine-5′-(alpha;-35S)-thiotriphosphate [Sp-dATP (α-35S)]

✍ K. M. Mathew; S. Ravi; C. V. Sontakke; H. Chander 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 107 KB

## Abstract Unprotected deoxyadenosine **1** was treated with an excess of phosphorus acid and stoichiometric proportions of __N__, __N__′‐di‐__p__‐tolylcarbodiimide in anhydrous pyridine to give deoxyadenosine‐5′‐monophosphite **2**. The latter was activated with trimethylsilyl chloride followed b