Modifications in Lipoprotein Surface Charge Alter Cyclosporine A Association with Low-Density Lipoproteins
β Scribed by Kishor M. Wasan; Olena Sivak
- Book ID
- 110416281
- Publisher
- Springer US
- Year
- 2003
- Tongue
- English
- Weight
- 124 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0724-8741
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π SIMILAR VOLUMES
The purpose of this study was to test the effect of modulating the expression of the human low-density lipoprotein receptor (LDLr) in human embryonic kidney (293T) cells on Cyclosporin A (CsA) cellular uptake and CsA-mediated cytotoxicity. LDLr expression was modulated using RNA interference (RNAi)
Two male Caucasian patients (36 and 42 years old) with heterozygous familial hypercholesterolemia and extremely elevated lipoprotein Lp(a) concentrations, resistant to diet and lipid-lowering drugs, were treated with low-density lipoprotein (LDL)-apheresis for 55 months (liposorber system, Kaneka@,