Modification of the 5' position of purine nucleosides. 1. Synthesis and biological properties of alkyl adenosine-5'-carboxylates
✍ Scribed by Prasad, Raj N.; Fung, Anthony; Tietje, Karin; Stein, Herman; Brondyk, Harold D.
- Book ID
- 126057209
- Publisher
- American Chemical Society
- Year
- 1976
- Tongue
- English
- Weight
- 770 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2623
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## Abstract Treatment of adenosine with PSCl~3~ in trimethyl phosphate gave, after ion‐exchange chromatography, adenosine‐5′‐__O__‐monophosphate (AMP; 28%) and adenosine‐5′‐__O__‐monothiophosphate (AMPS; 48%). AMPS was studied as a thiophosphate residue donor in an enzymatic transphosphorylation wi
Treatment of protected 5'-S-aryl (alkyl) thioadenosine sulfoxides (3) with diethylaminosulfur trifluoride (DAST)/antimony trichloride (SbC13) and deprotection resulted in high-yield syntheses of the new 5'-fluoro-5'-S-aryl (alkyl) thioadenosines (5).