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Modification of the 2′-position of purine nucleosides: syntheses of 2′-α-substituted-2′-deoxyadenosine analogs

✍ Scribed by R. Ranganathan

Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
291 KB
Volume
18
Category
Article
ISSN
0040-4039

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✦ Synopsis

Nucleoside analogs with stereochemical and/or functional group modifications in the sugar residue have shown promise as anti-tumor, 1 anti-viral, or immunosuppressive agents. In addition to these properties, adenosine analogs have been of interest as hypotensive agents, as inhibitors of platelet aggregation, and as radio-protective agents.

1.2 Among the nume r -

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