Modification of oral methotrexate absorption in children with leukemia
โ Scribed by Michael J. Mahony; Michael S. Murphy; Jane Wadsworth; Martin G. Mott
- Book ID
- 104684899
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 196 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0344-5704
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๐ SIMILAR VOLUMES
The relationship between salivary methotrexate (MTX) concentration and severity of oral mucositis after administration of MTX was investigated in six children with acute lymphoblastic leukemia. They received two administrations of MTX at 500 mgm' with one third given bolusly and the remainder by 24-
## Abstract From 1972 โ 1974, 228 children began treatment for acute lymphocytic leukemia and were prospectively assessed for neurologic complications. After CNS irradiation (2,400 rad) and intrathecal methotrexate (MTX), they received weekly intravenous maintenance therapy with MTX alone (40โ60 mg
Methotrexate (MTX) infusions of 500-1,000 mg/m2 over 24 hours may improve survival and prevent relapse in children with acute lymphoblastic leukemia (ALL). Childrens Cancer Group (CCG) Study 139 compared weekly oral methotrexate 20 mg/m2/ week (oral MTX) to MTX 500 mg/m2 infused over 24 hours (IV MT
We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (