Mitoxantrone is a substituted anthraquinone with considerable activity against human acute leukemia. The authors' goal was to treat patients with continuous infusion mitoxantrone in order to maintain cytotoxic steady state levels with acceptable toxicity and to assess the results. Daily mitoxantrone
Continuous infusion of methotrexate in children with acute leukemia
โ Scribed by Isaac Djerassi; Sidney Farber; Esshagh Abir; William Neikirk
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 732 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
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Methotrexate (MTX) infusions of 500-1,000 mg/m2 over 24 hours may improve survival and prevent relapse in children with acute lymphoblastic leukemia (ALL). Childrens Cancer Group (CCG) Study 139 compared weekly oral methotrexate 20 mg/m2/ week (oral MTX) to MTX 500 mg/m2 infused over 24 hours (IV MT
One hundred fifty-three children with ALL were diagnosed in Norway in the period August 1975-December 1980. One hundred ond remission. thirty-two of them received 3 infusions of methotrexate as consolidation therapy combined with methotrexate intrathecally as CNS prophylaxis. Eleven (44%) of the tot
## Abstract Twenty children with ALL that died in 1959โ1960 and 59 children with ALL that died in 1969 โ 1970 were analyzed according to the infections at both their terminal illness and their initial presentations. Despite the availability of more effective agents for pseudomonas and staphylococcu
The prognostic value of systemic clearance of methotrexate (MTX) has been evaluated in 58 children with acute lymphoblastic leukemia, receiving altogether 380 MTX infusions in a dose range of 0.5 to 33.6 g/mZ. The linear regression analysis of dose-steady state concentration relationship revealed th
## Abstract Continuation therapy using intermittent chemotherapy and BCG inoculation was commenced in 28 children with acute lymphocytic leukemia (ALL) immediately after remission induction and โCNS prophylaxis.โ At a median followup time of 17 months, 71% remain in total remission and 86% in bone