Modification of lung tumor development in A/J mice
β Scribed by H.P. Witschi; P.J. Hakkinen; J.P. Kehrer
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 500 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0300-483X
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Strain A mice develop a high incidence of spontaneous lung tumors during their lifetime. These tumors may be found in some animals as early as 3 to 4 weeks of age, increasing to nearly 100% by 24 months of age. The strain A mouse is also highly susceptible to the induction of lung tumors by several
Fibrosarcoma-SA-I -tumor-bearing mice were treated S.C. in the vicinity of tumors (peri-tumorally) or intravenously, with recombinant human TNF-a lacking I to 3 amino acids from N-terminal part (TNF-aNv3). Tumor growth delay, observed after both routes of TNF-aNv3 application, was statistically sign