A major goal in pre-clinical cancer chemoprevention research is to assess the predictive value of intermediate biomarker modulation towards tumor prevention. With this aim, BALB/c mice were treated with 10 daily i.p. injections of urethane (ethyl carbamate), each of 400 mg/kg body weight. Groups of
Cellular origin of urethane-induced lung tumors in strain a mice
โ Scribed by W.T. Gunning; G.D. Stoner; A.M. Malkinson; Peter J. Goldblatt
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 297 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0739-6260
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Strain A mice develop a high incidence of spontaneous lung tumors during their lifetime. These tumors may be found in some animals as early as 3 to 4 weeks of age, increasing to nearly 100% by 24 months of age. The strain A mouse is also highly susceptible to the induction of lung tumors by several
Mallory bodies (MBs) were induced in hepatic tumors by administration for up to 85 weeks of a diet containing 10 ppm dieldrin to 50 C3H/He and 62 C57BL/6J x C3H/He B6C3F1 male mice. MBs were seen in 15 of 28 (54%) mice which developed benign hepatic tumors and 33 of 45 (73%) mice with hepatocellular