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Modification of heart sarcolemmal Na+/K+-ATPase activity during development of the calcium paradox

✍ Scribed by Laurie E. Alto; Vijayan Elimban; Anton Lukas; Naranjan S. Dhalla

Book ID
110246745
Publisher
Springer
Year
2000
Tongue
English
Weight
113 KB
Volume
207
Category
Article
ISSN
0300-8177

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It is demonstrated a fast and significant depression in the sarcolemmal (Na,K)-ATPase activity that occurs as early as 25 sec after the onset of Ca2+ depletion, and participates in the development of Ca(2+)-paradox in the rat heart. Pretreatment of the animals with 7-oxo-prostacyclin (PGI2) 24-48 h