Modification of 5-fluorouracil activity by high-dose methotrexate or leucovorin in advanced colorectal carcinoma
β Scribed by Sinnige, Harm A.M.; Sleijfer, Dirk Th.; de Vries, Elisabeth G.E.; Willemse, Pax H.B.; Mulder, Nanno H.
- Book ID
- 123584649
- Publisher
- Elsevier Science
- Year
- 1990
- Weight
- 492 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0277-5379
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## Abstract Thirty patients with advanced measurable colorectal cancer were randomized to receive either methotrexate (MTX) 200 mg/m^2^ or 40 mg/m^2^, followed in four hours by 5βfluorouracil (5βFU) 600 mg/m^2^. Patients receiving the higher dose MTX were given leucovorin rescue 24 hours later. Eig
## BACKGROUND. The biochemical modulation of 5-fluorouracil (5-FU) by leucovorin (Lv) has demonstrated significantly increased response rates in comparison with the use of 5-FU alone in patients with advanced colorectal carcinoma. However, the higher response rate of LV/5-FU may occur at the expen
with low dose LV. Based on these reports, a first-line Phase II study was performed in 101 patients with advanced colorectal carcinoma who were given a bimonthly