Models of Independent Action for Combination Therapy

✍ Scribed by E. L. Korn

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 373 KB
• Volume: 27
• Category: Article
• ISSN: 0323-3847
• DOI: 10.1002/bimj.4710270711

✦ Synopsis

Two inethods of applying Finney's concept of simple independent action are suggested for examining possible synergiem in combination therapy. In one model the treatmente act independently at one time to cure the disease. In the other model the treatments act independently continuously to prevent the disease from progressing to 8 terminal outcome. The implications of these models for t.he interaction terme of a proportional hazarde model, a logdinear model on death rates, and a logistic model are discussed.