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A Simple Survival Model for Combined Action of Two Damaging Agents

✍ Scribed by M. Tanushev; E. M. Myasnikova; Dr. Sci A. Yu. Yakovlev

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 459 KB
Volume: 29
Category: Article
ISSN: 0323-3847
DOI: 10.1002/bimj.4710290117

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✦ Synopsis

The aim of thie study waa mathematical formalization of the development of two damage processes in response to the combined action of two different damaging agents. The model allows to obtain the parametric family of distributions for the life-epan when the orgsniem'e death is due to joint effect of two damage processes. Differing by their probabilistic meaning the notions of a priori (M(t)) and a posteriori (M(y)) conditional mean contributions of each damage proceas to the final effect of combined injury ere introduced. The formulae permitting to compute the M and Y values on the bask of survival data parametric analyeie are given.

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