𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Models of hepatic elimination

✍ Scribed by Richard A. Weisiger; Denis J. Morgan; D. Brian Jones; Michael S. Ching; Richard A. Smallwood

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
362 KB
Volume
6
Category
Article
ISSN
0270-9139

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✦ Synopsis

Models of Hepa

To the Editor:

A recent study by Jones and coworkers on the role of protein binding in hepatic drug elimination (1) warrants a second look. These authors found that increased extracellular binding due to addition of al-acid glycoprotein did not diminish the extraction of propranolol by the perfused rat liver. From this central finding, they reach a number of conclusions regarding the validity of various models of hepatic drug elimination. However, the authors do not address the possibility that their results may reflect Type I1 error: failure to confirm a valid hypothesis because of the insensitivity of the methods used.

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