Models of hepatic drug elimination: A response
โ Scribed by Denis J. Morgan
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 148 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Models of Hepa To the Editor: A recent study by Jones and coworkers on the role of protein binding in hepatic drug elimination (1) warrants a second look. These authors found that increased extracellular binding due to addition of al-acid glycoprotein did not diminish the extraction of propran
The distributed-tubes model of hepatic elimination is extended to include intermixing between sinusoids, resulting in the formulation of a new, interconnected-tubes model. The new model is analysed for the simple case of two interconnected tubes, where an exact solution is obtained. For the case of