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Modelling Neutral and Selective Evolution of Protein Folding

โœ Scribed by Lipman, D. J.; Wilbur, W. J.

Book ID
111928375
Publisher
The Royal Society
Year
1991
Tongue
English
Weight
972 KB
Volume
245
Category
Article
ISSN
0080-4649

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โœฆ Synopsis

We examine a model evolutionary space consisting of genotypes mapped to their corresponding phenotypes. This mapping is derived from a lattice model for proteins which, despite its highly idealized nature, has been shown to share general properties with real proteins. Large evolutionary networks are observed, with genotypes corresponding to non-lethal phenotypes linked by unit mutational steps. Neutral mutations are necessary for traversing the evolutionary networks, and even one neutral mutation in a genotype can change the phenotypes attainable by a unit mutational step.

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