We examine a model evolutionary space consisting of genotypes mapped to their corresponding phenotypes. This mapping is derived from a lattice model for proteins which, despite its highly idealized nature, has been shown to share general properties with real proteins. Large evolutionary networks are
โฆ LIBER โฆ
Modelling Neutral and Selective Evolution of Protein Folding
โ Scribed by Lipman, D. J.; Wilbur, W. J.
- Book ID
- 111928374
- Publisher
- The Royal Society
- Year
- 1991
- Tongue
- English
- Weight
- 972 KB
- Volume
- 245
- Category
- Article
- ISSN
- 0080-4649
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We stimulate the evolution of model protein sequences subject to mutations. A mutation is considered neutral if it conserves (1) the structure of the ground state, (2) its thermodynamic stability and (3) its kinetic accessibility. All other mutations are considered lethal and are rejected. We adopt