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Modelling a Spontaneously Reported Side Effect by Use of a Markov Mixed-Effects Model

✍ Scribed by Per-Henrik Zingmark; Matts Kågedal; Mats O Karlsson

Book ID
106423381
Publisher
Springer
Year
2005
Tongue
English
Weight
205 KB
Volume
32
Category
Article
ISSN
1573-8744

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✍ Pascal Girard; Terrence F. Blaschke; Helen Kastrissios; Lewis B. Sheiner 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB 👁 2 views

Patient compliance (adherence) with prescribed medication is often erratic, while clinical outcomes are causally linked to actual, rather than nominal medication dosage. We propose here a hierarchical Markov model for patient compliance. At the first stage, conditional upon individual random effects