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A pharmacodynamic Markov mixed-effect model for the effect of temazepam on sleep

โœ Scribed by Karlsson, M

Book ID
111726809
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
171 KB
Volume
68
Category
Article
ISSN
0009-9236

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โœ Pascal Girard; Terrence F. Blaschke; Helen Kastrissios; Lewis B. Sheiner ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 261 KB ๐Ÿ‘ 2 views

Patient compliance (adherence) with prescribed medication is often erratic, while clinical outcomes are causally linked to actual, rather than nominal medication dosage. We propose here a hierarchical Markov model for patient compliance. At the first stage, conditional upon individual random effects