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Modeling the reaction mechanisms for redox regulation of protein tyrosine phosphatase 1B activity

✍ Scribed by Ning Liu; Russell J. Boyd

Publisher
Springer
Year
2007
Tongue
English
Weight
408 KB
Volume
118
Category
Article
ISSN
1432-2234

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Protein tyrosine phosphatases are a class of enzymes that function to modulate tyrosine phosphorylation of cellular proteins and play an essential role in regulating cell function. PTP1B has been implicated in the negative regulation of the insulin signaling pathway by dephosphorylating the activate