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Modeling the crystal morphology of α-lactose monohydrate

✍ Scribed by Graham Clydesdale; Kevin J. Roberts; Gillian B. Telfer; David J. W. Grant

Book ID
109388505
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
328 KB
Volume
86
Category
Article
ISSN
0022-3549

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The dissolution kinetics of alpha-lactose monohydrate (alphaLM) single crystals were studied by a flow-cell method at different undersaturations. Linear dissolution profiles were obtained as a function of time for all the faces except the (010) face. The dissolution rates, obtained from these profil

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The bulk crystallization of a-lactose monohydrate from aqueous solution by primary nucleation has been studied under controlled conditions of supersaturation, temperature, and pH. The induction times to nucleation were extremely long compared with those generally observed for other materials, even a

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Some observations on the milling of a-lactose monohydrate with a Retsch single-ball mill are reported. The effects of mill loading and frequency of the mill motion were investigated. At a given frequency, a lower mill loading showed a higher milling efficiency. For a given mill loading, size reducti