๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Modeling T Cell-Antigen Presenting Cell Interactions

โœ Scribed by Michael A. Fishman; Alan S. Perelson

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
897 KB
Volume
160
Category
Article
ISSN
0022-5193

No coin nor oath required. For personal study only.

โœฆ Synopsis

We present and analyze a model for the interaction of naive T cells with antigen presenting cells (APCs) that results in T-cell activation. We use this model to examine delayed type hypersensitivity (DTH) reactions. We show that responses can be of two types; either the antigen is completely eliminated or the immune system fails to eliminate the antigen and chronic infection results. Both outcomes are characteristic of diseases in which delayed type hypersensitivity is the primary defense mechanism. We compare the effectiveness of two types of APCs macrophages and dendritic cells, in the generation of DTH responses. We conclude that dendritic cells are more suited to the task of stimulating naive T cells than are macrophages, as has recently been argued by Steinman and coworkers.

๐Ÿ“œ SIMILAR VOLUMES

Antigen presentation by liposomes as mod
Antigen presentation by liposomes as model system for T-B cell interaction
โœ Peter Walden ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 378 KB

Using the earlier established liposome system for antigen presentation, in which liposomes bearing major histocompatibility complex (MHC)-class II molecules inserted into and protein antigen covalently linked to the membrane were found to be sufficient for an antigen-specific and MHC-restricted acti

Antigen presenting cells and T cell inte
Antigen presenting cells and T cell interactions in the gastrointestinal tract
โœ Thomas T. MacDonald; Anna Voessenkamper; Antonio Di Sabatino ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 663 KB

## Abstract Dendritic cells make up less than 1% of the cells in lymph nodes and tissues, but they are critical in initiating and directing T cell immune responses. In the gut, with exposure to myriad food and bacterial antigens, they probably control T cell unresponsiveness to food antigens and T