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Modeling, Prediction, and in Vitro in Vivo Correlation of CYP3A4 Induction

✍ Scribed by Shou, M.; Hayashi, M.; Pan, Y.; Xu, Y.; Morrissey, K.; Xu, L.; Skiles, G. L.

Book ID
124048630
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2008
Tongue
English
Weight
872 KB
Volume
36
Category
Article
ISSN
0090-9556

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In Vitro/in Vivo scaling of alprazolam m
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✍ Noriko Hirota; Kiyomi Ito; Takafumi Iwatsubo; Carol E. Green; Charles A. Tyson; πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 243 KB πŸ‘ 1 views

We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a