We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a
β¦ LIBER β¦
Induction of CYP3A by Ethanol in Multiple In Vitro and In Vivo Models
β Scribed by Dennis E. Feierman; Zoya Melinkov; Amin A. Nanji
- Book ID
- 109123339
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 276 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0145-6008
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