Modeling Phasic Insulin Release: Immediate and Time-Dependent Effects of Glucose
β Scribed by Nesher, R.; Cerasi, E.
- Book ID
- 118001173
- Publisher
- American Diabetes Association
- Year
- 2002
- Tongue
- English
- Weight
- 150 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0012-1797
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π SIMILAR VOLUMES
The effects of the alpha and beta anomers of D-glucose on insulin release were studied in a rat model of non-insulin-dependent diabetes, which was induced by streptozotocin injection at 2 days of age. Glucose tolerance of the streptozotocin-treated rats at 8-10 weeks of age was mildly diabetic. Insu
The isolated perfused rat pancreas was stimulated sequentially with arginine or glucose to analyze the time-dependent modulation of insulin release. A 10-min perfusion with arginine (5.0 mmol/l) induced 75% inhibition of the insulin response to repeated arginine stimulation 10 min later. When glucos