✦ LIBER ✦

Insulin release by glucose anomers in a rat model of non-insulin-dependent diabetes

✍ Scribed by A. Niki; H. Niki; I. Niki; Y. Kunoh

Publisher: Springer
Year: 1988
Tongue: English
Weight: 269 KB
Volume: 31
Category: Article
ISSN: 0012-186X
DOI: 10.1007/bf00279137

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✦ Synopsis

The effects of the alpha and beta anomers of D-glucose on insulin release were studied in a rat model of non-insulin-dependent diabetes, which was induced by streptozotocin injection at 2 days of age. Glucose tolerance of the streptozotocin-treated rats at 8-10 weeks of age was mildly diabetic. Insulin release from the isolated perfused pancreas of the diabetic rats in response to 10 mmol/l alpha-D-glucose was markedly impaired, while insulin response to 10 mmol/l beta-D-glucose in the diabetic pancreas was only slightly reduced as compared to that in the control pancreas.

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