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Modeling of the Bryostatins to the Phorbol Ester Pharmacophore on Protein Kinase C

✍ Scribed by Paul A. Wender, Cynthia M. Cribbs, Konrad F. Koehler, Nancy A. Sharkey, Cherry L. Herald, Yoshiaki Kamano, George R. Pettit and Peter M. Blumberg

Book ID
123635826
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
943 KB
Volume
85
Category
Article
ISSN
0027-8424

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## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC down‐regulation by the phorbol ester 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo