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Model studies of thymidylate synthetase. Intramolecular catalysis of 5-hydrogen exchange and 5-hydroxymethylation of 1-substituted uracils

✍ Scribed by Santi, Daniel V.; Brewer, Curtis F.


Book ID
126829309
Publisher
American Chemical Society
Year
1973
Tongue
English
Weight
996 KB
Volume
12
Category
Article
ISSN
0006-2960

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In order to explain different activities shown by 5-hydroxy-dUMP (substrate) and its close analogue 5-hydroxymethyl-dUMP (slow-binding inhibitor) in the reaction catalyzed by thymidylate synthase, studies have been undertaken involving (i) ab initio RHF simulations, (ii) comparative analysis of crys