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Antiviral, antitumor, and thymidylate synthetase inhibition studies of 5-substituted styryl derivatives of 2′-deoxyuridine and their 5′-phosphates

✍ Scribed by Erik De Clercq; Jan Balzarini; Johan Descamps; Christopher F. Bigge; Charles T.-C. Chang; Panos Kalaritis; Mathias P. Mertes


Book ID
115775986
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
671 KB
Volume
30
Category
Article
ISSN
0006-2952

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Antitumor cell and antimetabolic effects
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A series of forty 5'-ester derivatives of 5-ethyl-2'-deoxyuridine (EDU) have been evaluated for their inhibitory effects on the growth and metabolism of routine leukemia L1210 cells. Several EDU esters proved as potent as EDU in their inhibitory effects on L1210 cell growth (inhibitory dose-50: 5-10