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Model studies for the synthesis of clavulactone

โœ Scribed by Zhihong Zeng; Xingxiang Xu


Book ID
108379719
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
107 KB
Volume
41
Category
Article
ISSN
0040-4039

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A stereoselective synthesis of all functionalized C2-C10 fragment 13 of the antitumor marine natural product clavulactone was accomplished, starting from the commercially available 3-methylglutaric acid anhydride. Desymmetrization of 3-methylglutaric acid anhydride with (S)-ฮฑ-phenylethanamine was su