𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Model studies directed toward the avermectins: A route to the oxahydrindene subunit

✍ Scribed by David M. Armistead; Samuel J. Danishefsky

Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
180 KB
Volume
28
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A MlchaeCAldol sequence of an enoate-ketone triggered by the action of an aluminum thiophenoxy "ate" complex leads to the oxahydrindene subunit of the avermectins.

📜 SIMILAR VOLUMES

A novel synthetic route to the hexahydro
A novel synthetic route to the hexahydrobenzofuran subunit of the avermectins and milbemycins
✍ Stephen Hanessian; Pierre Beaulieu; Daniel Dubé 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 246 KB

Radical-induced intramolecular Michael cyclization of a bromovinyl-type appendage onto a functionalized cyclohexene carboxylic acid derivative produces the corresponding oxahydrindanes which can be transformed into oxahydrindenes (hexahydrobensofurans) related to the title compounds. (-)-Quinic acid

ChemInform Abstract: Model Studies Direc
ChemInform Abstract: Model Studies Directed Toward the Total Synthesis of (.+-.)-Ribasine. A Tandem Cyclization—Cycloaddition Route Leading to the Core Skeleton.
✍ Albert Padwa; Laura Precedo; Mark A. Semones 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

Model Studies Directed Toward the Total Synthesis of (±)-Ribasine. A Tandem Cyclization-Cycloaddition Route Leading to the Core Skeleton. -A tandem cyclization-cycloaddition sequence of model compound (II) represents a useful approach towards the synthesis of the oxabicyclo[3.2.1]octane ring system