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Model-specific selection of molecular targets for heart failure gene therapy

✍ Scribed by Michael G. Katz; Anthony S. Fargnoli; Catherine E. Tomasulo; Louella A. Pritchette; Charles R. Bridges

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
660 KB
Volume
13
Category
Article
ISSN
1099-498X

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✦ Synopsis

Abstract

Heart failure (HF) is a complex multifaceted problem of abnormal ventricular function and structure. In recent years, new information has been accumulated allowing for a more detailed understanding of the cellular and molecular alterations that are the underpinnings of diverse causes of HF, including myocardial ischemia, pressure‐overload, volume‐overload or intrinsic cardiomyopathy. Modern pharmacological approaches to treat HF have had a significant impact on the course of the disease, although they do not reverse the underlying pathological state of the heart. Therefore gene‐based therapy holds a great potential as a targeted treatment for cardiovascular diseases. Here, we survey the relative therapeutic efficacy of genetic modulation of β‐adrenergic receptor signaling, Ca^2+^ handling proteins and angiogenesis in the most common extrinsic models of HF. Copyright © 2011 John Wiley & Sons, Ltd.

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