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Model Organisms in Drug Discovery || Drosophila– a Model System for Targets and Lead Identification in Cancer and Metabolic Disorders

✍ Scribed by Carroll, Pamela M.; Fitzgerald, Kevin

Publisher
John Wiley & Sons, Ltd
Year
2003
Tongue
English
Weight
595 KB
Category
Article
ISBN-13
9780470014066

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✦ Synopsis

Genetic and genomic research in model organisms has tremendously accelerated our understanding of the basic biological processes that lie at the heart of human disease. The genetic dissection of disease-relevant signaling pathways in Drosophila offers an ideal tool to identify novel drug targets for human diseases. In this chapter we outline the conservation of signaling pathways and the different tools available in Drosophila that are suitable for target identification and target validation, as well as for direct screening for biologically active low-molecular-weight compounds.

5.1 Evolutionary conservation of disease-related pathways in Drosophila

Analysis of the genetic basis of the development of invertebrate model organisms such as Drosophila melanogaster and Caenorhabditis elegans has confronted us with a stunning degree of conservation of basic developmental processes in invertebrates and disease-related processes in humans. Of more than 1000 genes associated with human diseases, 77% are conserved in

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✍ Carroll, Pamela M.; Fitzgerald, Kevin 📂 Article 📅 2003 🏛 John Wiley & Sons, Ltd 🌐 English ⚖ 426 KB 👁 2 views

Yeast has great utility as a surrogate system to study aspects of mammalian biology. This utility extends to the drug discovery process, where yeast has been used to reveal the mechanism of action of compounds, to discover and characterize components of signaling pathways and to dissect protein func