A very efficient algorithm for determining the geometrically feasible binding modes of a flexible ligand molecule at the receptor site is presented. It is based on distance geometry but maintains the requirements of three dimensions. The distance geometry manipulation can superimpose two bodies with
β¦ LIBER β¦
Model of the whole rat AT1receptor and the ligand-binding site
β Scribed by Camelia Baleanu-Gogonea; Sadashiva Karnik
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 730 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1610-2940
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## Abstract Computerβbased homology modeling techniques were used to construct a threeβdimensional model of the __Escherichia coli__ serine receptor ligandβbinding domain based on the crystal structure of the __Salmonella typhimurium__ aspartate receptor and the sequence homology between the two re