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Model catalysts which simulate penicillinase IV: Steric and electronic effects in the catalysis of hydrolysis of penicillins and cephalothin by aminoalkylcatechols

โœ Scribed by Renaat D. Kinget; Michael A. Schwartz


Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
374 KB
Volume
58
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES


Model catalysts which simulate penicilli
โœ Michael A. Schwartz; Gerald R. Pflug ๐Ÿ“‚ Article ๐Ÿ“… 1967 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 519 KB

the first time, a synthetic method for labeling the carbon skeleton of tropine, for synthesizing tropinelabeled atropine, and for synthesizing labeled intermediates between arabinose and tropine. Fur- ther studies will be published in the third paper of this series.

Model catalysts which simulate penicilli
โœ Michael A. Schwartz ๐Ÿ“‚ Article ๐Ÿ“… 1965 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 391 KB ๐Ÿ‘ 1 views

Further studies on the nature of the catalysis of hydrolysis of penicillin G by 3,6-bis-(dimethylaminomethy1)catechol (CDM) show that the active species of this compound (+ 1 charge) interacts by electrostatic attraction with the negatively charged penicillin. The 3,5-substituted catechol shows no H

Model catalysts which simulate penicilli
โœ Renaat D. Kinget; Michael A. Schwartz ๐Ÿ“‚ Article ๐Ÿ“… 1968 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 526 KB

Studies of catalysis of hydrolysis of benzylpenicillin by aminoalkylcatechols have been extended to a series of morpholinomethyl derivatives of catechol and pyrogallol. Catalytic rate constants for each of the active s ecies are related to their basicity and presence or absence of electrophilic grou