Studies of catalysis of hydrolysis of benzylpenicillin by aminoalkylcatechols have been extended to a series of morpholinomethyl derivatives of catechol and pyrogallol. Catalytic rate constants for each of the active s ecies are related to their basicity and presence or absence of electrophilic grou
Model catalysts which simulate penicillinase II. Mechanism of hydrolysis of penicillins catalyzed by catechol
✍ Scribed by Michael A. Schwartz; Gerald R. Pflug
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 519 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
the first time, a synthetic method for labeling the carbon skeleton of tropine, for synthesizing tropinelabeled atropine, and for synthesizing labeled intermediates between arabinose and tropine. Fur- ther studies will be published in the third paper of this series.
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Further studies on the nature of the catalysis of hydrolysis of penicillin G by 3,6-bis-(dimethylaminomethy1)catechol (CDM) show that the active species of this compound (+ 1 charge) interacts by electrostatic attraction with the negatively charged penicillin. The 3,5-substituted catechol shows no H
## Abstract A series of highly preorganized pyrazolate‐based dinuclear zinc complexes has been studied as functional synthetic analogues of metallo‐β‐lactamases, a class of bacterial enzymes that cause serious clinical problems because of their degradation of common β‐lactam antibiotics. We have in