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Mobilization of intracellular iron by analogs of pyridoxal isonicotinoyl hydrazone (PIH) is determined by the membrane permeability of the iron–chelator complexes

✍ Scribed by Joan L Buss; Emmanuele Arduini; Prem Ponka


Book ID
113993290
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
467 KB
Volume
64
Category
Article
ISSN
0006-2952

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Partition coefficients of the iron(III)
✍ J. T. Edward; P. Ponka; D. R. Richardson 📂 Article 📅 1995 🏛 Springer Netherlands 🌐 English ⚖ 558 KB

Pyridoxal isonicotinoyl hydrazone and its analogs are orally effective Fe(llI) chelators which show potential as drugs to treat iron overload disease. The present investigation describes the measurement of the partition coefficient of the apochclator and Fe(lll) complex of 20 of these ligands. These