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Lipophilicity of analogs of pyridoxal isonicotinoyl hydrazone (PIH) determines the efflux of iron complexes and toxicity in K562 cells

✍ Scribed by Joan L. Buss; Emmanuele Arduini; Kyle C. Shephard; Prem Ponka


Book ID
113993348
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
443 KB
Volume
65
Category
Article
ISSN
0006-2952

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Partition coefficients of the iron(III)
✍ J. T. Edward; P. Ponka; D. R. Richardson πŸ“‚ Article πŸ“… 1995 πŸ› Springer Netherlands 🌐 English βš– 558 KB

Pyridoxal isonicotinoyl hydrazone and its analogs are orally effective Fe(llI) chelators which show potential as drugs to treat iron overload disease. The present investigation describes the measurement of the partition coefficient of the apochclator and Fe(lll) complex of 20 of these ligands. These